在第15个内含子中插入了loxP引导的诺卡因载体,然后对编码一个自磷酸化位点和磷脂酶Cγ结合位点的序列进行了点突变,将对应的氨基酸从酪氨酸替换为苯丙氨酸。这是一种功能减弱的等位基因。(来源:J:49154)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
Insertion, Nucleotide substitutions
--
1
25
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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