在loxP位点介导下,一个含有3-6号外显子的诺姆西林载体替换了包含部分跨膜区和蛋白质外区的基因组片段。Northern blot结果显示,纯合小鼠骨骼肌中未检测到转录本,而 Western blot 和免疫组化分析则证实了这些肌肉中该蛋白在肌膜上完全缺失。(来源:J:60154)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
7
17

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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