一种新霉素抗性基因座替换了包含第六外显子的基因片段。RT-PCR分析显示,纯合子小鼠从这个缺少第六外显子序列的等位基因产生了内切框转录本。 Western blot分析鉴定出了来自这个等位基因的蛋白质,推测其缺少α2(V)链的N-端延伸片段。(来源:J:22301)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
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1
3
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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