一种由人类β-actin启动子驱动表达猪lectin cDNA的构建被注入到受精卵中。该构建在Pcdh15基因的编码区域以多拷贝串联方式整合,干扰了第四cdh域的编码序列。这种等位基因产生了剪接异常的转录本,由于转基因中包含的SV40poly(A)位点,它们的大小小于正常。(来源:J:66738)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
FVB/N
--
插入
隐性
1
10
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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