这个等位基因是Sema3ctm1Jra衍生的,通过小鼠中携带Sema3c基因与表达Cre重组酶的雄性小鼠杂交,去除了新霉素抗性基因。在E12.5期同源异型突变胚胎的原位杂交中,几乎检测不到mRNA。这些胚胎的RT-PCR分析在靶序列的5'和3'端检测到了转录本,但未在靶序列内部区域发现转录本。(来源:J:71240)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
1
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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