在基因的5' UTR位置360号位置插入了一个floxed PGK-betageo选择子。通过定点PCR的同位素直接突变,将丝氨酸的63和73位替换为 Alanine(S63A和S73A)。这个突变体通过将表达Cre的质粒通过核内注射移除携带的floxed PGK-betageo元件。(来源:J:53481)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
核苷酸替换
--
1
--
13

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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