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中文
将5号外显子替换为hygromycin载体导致4号和6号外显子间产生了一个框移。来自纯合突变小鼠大脑、肾脏、肺、心脏和肝脏的RNANorthern印迹确认了Psen2基因的全基因突变。使用针对Psen2蛋白N端和C端特异抗体的同源突变小鼠组织 Western blot，也证实了这一突变。(来源：J:58118)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
