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中文
将大部分第一个外显子替换为一个内切位点loxP介导的氨苄青霉素抗性基因 cassette，该基因位于lacZ基因的3'端。在产生嵌合小鼠之前，通过Cre介导的重组在ES细胞中移除了这个neomycin抗性元件。这个lacZ基因等位基因在内源性启动子元件的调控下表达β-半乳糖苷酶。(来源：J:61882)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
