在PGK-neomycin抗性 cassette插入的位置,大约替换了Clcnk1基因的8kb区域,包括1-8号外显子。纯合突变小鼠在RNA保护分析中没有检测到Clcnk1 mRNA的表达。通过免疫组化分析,蛋白缺失在鼠肾中得到了确认。(来源:J:51917)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
7
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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