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The genetic position, based on an analysis of 656 backcross progeny, localized to a 2.3-Mb region spanning from 422 kb upstream to 1.8 Mb downstream of the Pvrl3 transcription unit. However, sequencing of Pvrl3 exons and splice junctions in mutants failed to detect an intragenic mutation. Never the less, the Pvrl3 expression domain in the prospective ciliary epithelia in homozygous mice was reduced to background levels but Pvrl3 expression in the embryonic and postnatal lens of homozygotes appeared similar to wild type. (J:180113)