在第六个密码子之后插入了一个neomycin抗性基因 cassette,lacZ 基因则紧接着。 Western blot结果显示,来自纯合小鼠的晶状体匀浆中未检测到 GJA8 蛋白。这个等位基因在内源性启动子的调控下表达β-半乳糖苷酶。(来源:J:73651)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
8
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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