一种新霉素抗性 cassette 替换了 0.8kb 的序列,包括维持激酶活性必需的 invariantlysine 的密码子。北向印迹分析未在纯合小鼠大脑中检测到正常转录本,但检测到了与突变等位基因预测产物大小相符的多个转录本。(来源:J:23852)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv-Gpi1c
Targeted
插入,基因内删除
--
1
23
58

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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