将3、4和5号外显子替换为插入内切位点在3号外显子中的新霉素抗性基因。通过Northern blot分析,来自纯合突变小鼠产生的巨噬细胞中未检测到mRNA。通过ELISA实验,给纯合突变小鼠静脉注射脂多糖后,血清中未检测到蛋白质。(来源:J:46514)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
221

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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