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An IRES-lacZ cassette followed by a loxP-flanked neomycin resistance cassette replaced a genomic fragment containing the coding region of exon 2 and all of exon 3. This allele encodes the heart- and lung-specific c isoform in the absence of the a and b isoforms. The presence of the retained neomycin resistance cassette results in a hypomorphic allele. (J:69854)