将编码PDGFβR的cDNA插入到Pdgfrb基因位点。这个等位基因作为Pdgfrbtm5Sor的对照。cDNA在第二编码外显子的Sma1位点内正确地插入了。 Western blot结果显示,靶向插入的Pdgfr基因表达受到了干扰,引入的受体得以表达。(来源:J:67735)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJaeSor
Targeted
插入
--
1
11
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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