将新霉素抗性基因 cassette 插入到第 8 个外显子导致 Xrcc1 基因发生插入,替换 8 个编码碱基。 Western blot 检测在来自 8.5 天胚胎的细胞系总蛋白提取物中未发现 XRCC1 蛋白或截断产物,这些细胞系是 Xrcc1tm1Rpe 和 Trp53tm1Tyj 的纯合子。(来源:J:54226)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入,基因内删除
--
1
1
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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