在RGD序列5'端插入抗氨苄青霉素抗性基因 cassette,导致Spp1基因发生插入突变。北向分析显示,纯合突变鼠肾组织检测到少量高分子量RNA,但未发现野生型或剪切过的Spp1转录本。免疫印迹分析在骨组织中检测到了少量截短形式的蛋白质,但在其他组织、液体或纯合突变鼠的细胞中未发现。(来源:J:56535)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入
--
1
2
94

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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