Vim基因的Exon1被LacZ抗氨苄青霉素抗性 cassette插入,导致了失活。在纯合突变动物的器官中,Northern分析未检测到Vim转录本。 Western分析、免疫荧光显微镜和免疫组化研究在纯合突变小鼠的组织中也未发现VIM蛋白。内源性Vim启动子控制了靶向等位基因的β-半乳糖苷酶表达。(来源:J:21588)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入
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1
2
58

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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