在TGK-neomycin抗性 cassette插入了从exon 2到exon 13的序列,该 cassette使得lacZ序列与内源性启动子成框架。作者推测,目标等位基因不会产生功能蛋白,而是由内源性启动子控制的β-半乳糖苷酶融合蛋白。在杂合突变小鼠的乳汁腺中, Western 分析未检测到野生型蛋白。(引用: J:62724)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
--
37

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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