Rarg^tm1Ipc

Insertion of a neomycin resistance cassette into exon 8 at the position corresponding to amino acid 75 of the gamma1 isoform disrupted Rarg in the B region common to all isoforms. This disruption is predicted to prevent the synthesis of all RARG isoforms. RNase protection analysis of E13.5 embryos indicated that the mRNAs encoding the both the gamma1 and the gamma2 isoforms were mutated in this allele, and did not detect the wild-type transcript for either isoform. (J:12691)