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在exon 6中插入了一个新霉素表达元件，删除了编码活性部位的31bp序列，导致插入后序列错位。对小鼠脾脏RNA的Northern blot分析显示，纯合子中正常转录本缺失。Western blot分析显示，纯合子小鼠的腹膜巨噬细胞中未表达该蛋白质。这个突变是在无Casp11蛋白表达的ES细胞中产生的(Casp129mt)。(来源：J:22964)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
