一个新霉素抗性基因座替换了编码第3外显子大部分、其后的内含子序列以及第4外显子5'端的基因,该基因编码70-160个氨基酸。对E11.5胚胎进行的Northern和Western印迹实验显示了目标基因的mRNA和蛋白质均未检测到(来源:J:64280)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
7
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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