通过同源重组插入了一个lacZ-PGK-neo cassette,导致该基因大部分产品被删除,包括所有LXXLL结构和核受体共激活因子的功能丧失。在来自纯合突变胚胎的成纤维细胞中进行的报告基因实验表明,表达显著减少。(来源:J:61840)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
隐性
1
--
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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