使用了一盒包含lacZ编码序列和新霉素抗性基因的带子,它取代了编码DNA结合区域的第4和5个外显子。这种插入使得β1和β2的两种形式都失活。通过RT-PCR技术,证实了纯合突变动物中没有mRNA存在。(来源:J:52829)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
插入,基因内删除
--
1
5
33

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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