删除编码区域的4-14个外显子,如下:在第3内含子中插入了PGK-neomycin cassette,两侧带有两个loxP位点,而在14号外显子中也插入了loxP位点。携带这种等位基因的鼠与CMV-Cre转基因鼠杂交,产生了删除了loxP位点序列的鼠。(来源:J:62628)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
基因内删除
隐性
1
2
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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