包含2号外显子和3号部分内含子的基因片段被替换为带有splice接受器和诺卡因选择标记的lacZ基因。逆转录-PCR结果显示,这种突变去除了野生型转录本的表达,而全身胚胎染色实验表明,这个等位基因产生了β-半乳糖苷酶。(来源:J:62025)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
1
21

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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