在基因的第四外显子336位插入了一段耐氨苄青霉素的基因,导致在下游21个核苷酸的位置形成一个终止密码子。针对该基因的转录在来自两个双靶向ES细胞系提取的RNA Northern印迹中未检测到转录本。在两个双靶向ES细胞系提取的蛋白质 Western印迹中,也未检测到目标基因的蛋白质产物。(来源:J:44428)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
STOCK 129/Sv and C57BL/6J and SJL
Targeted
插入
--
1
15
26

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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