在第2外显子中,一个新霉素抗性基因座替换了起始翻译位点及其下游序列。Northern印迹和Western印迹分析证实了这个等位基因不表达(数据未显示)。免疫细胞化学研究在成年转基因雄性小鼠的海马冠状切片中未检测到蛋白质(J:34606)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv-Gpi1c
Targeted
插入,基因内删除
--
1
--
21

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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