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An nLacZ gene is fused in-frame to the DNA sequences encoding the first 13 amino acids, resulting in a disruption of the gene and expression of nLacZ under the transcriptional regulation of the endogenous promoter. A neomycin resistance cassette, RNA polymerase II promoter and 3' sequence of the HPRT gene were introduced after the reporter gene. (J:36716, J:39308, J:92799)