Cryba1^Po1

The mutation is a T-to-A transversion at the second base of exon 6, altering this codon from a tryptophan to an arginine. The mutation also leads to an additional splicing signal, skipping the first 3 bp of exon 6 and deletion of the codon from the encoded mRNA. Both types of mRNA are present in homozygous mutant lenses. The fourth Greek key motif of the protein is predicted not to form as a result of these mutations. (J:58912)