将一个新霉素插件插入到A和B两种异构体编码起始密码子下游的第一个外显子中,以有效地阻断这两种异构体的转录。北向分析显示没有特异基因的转录本。对于孕激素受体的竞争性结合分析表明,纯合突变动物中没有功能的蛋白存在。(来源:J:28980)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
插入,基因内删除
--
1
1
72

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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