"撞击与逃跑"型策略用于在基因中制造一个三核苷酸缺失,删除了苯丙氨酸密码子508(p.F508del),从而建立了模拟人类囊性纤维化患者中发现的deltaF508突变的鼠模型。(来源:J:28979)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
基因内删除
--
1
12
61

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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