Pitx2^tm2Sac

This allele is derived from Pitx2tm1Sac. Gene targeting was performed with a vector engineered to contain a loxP site downstream from exon 4 and a floxed neomycin cassette upstream of exon 4. Subsequent cre expression resulted in deletion of both the neo selection cassette and exon 4. This allele is a demonstrated to be a functional null. (J:51160)