在exon 1的编码区域插入了新霉素抗性基因座。对 sciatic 髓神经提取物的 Western blot 检测显示,纯合子小鼠中该蛋白缺失。神经功能活性测定也证实了 sciatic 髓神经提取物中没有功能蛋白(来源:15313)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入
--
1
--
28

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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