这种突变是一个包含D17Aus9位点的删除,它是通过将诺卡因/胸腺嘧啶激酶的选择性载体通过同源重组插入到D17Aus9位点,然后对这些ES细胞进行辐射处理,并筛选出不再表达胸腺嘧啶激酶的细胞系。接着,这些ES细胞系被用来培育杂合小鼠。 (Source: The mutation description and process)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(BALB/cJ x 129S4/SvJae)F1
Radiation induced
删除
--
--
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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