这种突变是一个包含D17Aus9位点的删除,它是通过将诺卡因/胸腺嘧啶激酶的选择性载体通过同源重组插入到D17Aus9位点,然后对这些ES细胞进行辐射处理,并筛选出不再表达胸腺嘧啶激酶的细胞系。接着,这些ES细胞系被用来培育杂合小鼠。 (Source: The mutation description and process)
Basic Information
(BALB/cJ x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count