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在PGK-羟氨苄青霉素抗性基因插入后，加上接头序列，导致第四外显子产生了一个框内终止密码子。通过Northern分析，确认了纯合突变体动物（J:50582）中没有转录本存在。 (Source: Northern analysis was used to confirm the absence of transcript in homozygous mutant animals (J:50582) from the insertion of a PGK-hygromycin resistance gene with adapter sequences, which resulted in an in-frame stop codon in exon 4.)