两种导向载体被用来产生两种特异性突变,但论文中并未明确区分。载体582通过插入诺卡因基因,替换Tal1基因编码的b-HLH区域来实现这一点。载体607则是通过替换单位b-HLH区域的序列,用的是韩高霉素基因,同样作用于Tal1基因。(来源:J:27458)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
隐性
1
1
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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