将新霉素抗性基因座插入Alox15基因的第3外显子导致了基因的插入突变。对同源纯合突变小鼠的腹腔巨噬细胞和骨髓来源巨噬细胞的Northern blot检测未发现转录本。而对同源突变小鼠的腹腔巨噬细胞进行 Western blot 分析,也未检测到ALOX15蛋白。(参考文献:J:44778)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入
--
1
--
108

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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