在含有编码N端SH2区域序列的基因组片段被替换成新霉素 cassette 后,对胚胎总蛋白提取物进行 Western blot 分析表明,纯合子小鼠中没有产生 RASA1 蛋白。(来源:J:29825)
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A neomycin cassette replaced a genomic fragment containing sequences encoding the N-terminal SH2 domain. Western blot analysis of total embryo protein lysates showed that no RASA1 protein was produced in homozygous mice. (J:29825)