编码前导肽区域的序列被替换了新霉素抗性基因座。RT-PCR结果显示,来自纯合小鼠整个大脑RNA中该转录本缺失。免疫组化分析显示,纯合小鼠大脑杏仁核和大脑皮层的切片中未检测到该蛋白。(来源:J:17994, J:23082, J:47705)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
1
45

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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