Exon 2,编码信号肽区域的,被诺卡因 cassette 的插入所打断。为了确认基因正确靶向,用脂多糖 (LPS) 对小鼠进行挑战,这会导致野生型小鼠中 Tnfrsf1b 的外膜域脱落。同性别的突变动物血清中未检测到可溶性 Tnfrsf1b。(来源:J:21815)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入
--
1
2
189

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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