一种新霉素抗性基因座替换了编码核苷酸结合域的那个包含2.5kb序列的exon。对总脑RNA的Northern印迹分析显示,纯合突变小鼠缺乏正常转录本。对总脑蛋白的Western印迹分析并未在纯合突变小鼠中检测到该蛋白质。(来源:J:16392)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
1
41

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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