在exon 2中插入了新霉素选择座。对来自经LPS刺激的纯合小鼠巨噬细胞提取的RNA进行RT-PCR实验后,未检测到这个等位基因产生的可检测转录物。ELISA和生物活性实验也确认了纯合小鼠中未产生功能蛋白。(来源:J:17360)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入
--
1
7
688

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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