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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Il6
tm1Kopf
Alias:
Il6
tm1Koe
Il6-
Il6
tm1Kopf
IL-6 KO
IL-6-
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基础信息
表型特征
文献报道
在exon 2中插入了新霉素选择座。对来自经LPS刺激的纯合小鼠巨噬细胞提取的RNA进行RT-PCR实验后,未检测到这个等位基因产生的可检测转录物。ELISA和生物活性实验也确认了纯合小鼠中未产生功能蛋白。(来源:J:17360)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
1857197
129S2/SvPas
Targeted
插入
--
1
7
688
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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