一个PGK-新霉素抗性 cassette替换了包括起始翻译位点和信号序列部分的0.8kb基因。杂合子的纤维蛋白原血浆浓度是对照野生型同胞的一半。在来自纯合突变E7.5胚胎培养物的免疫沉淀中,编码蛋白无法检测到。(来源:J:16247)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
2
13

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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