在第2外显子插入了新霉素选择座,使得一个新密码子在整合位点下游239bp处形成,导致终止密码。对来自纯合小鼠激活的巨噬细胞、肥大细胞和自然杀伤细胞的RNA进行RT-PCR分析,未检测到此等位基因的转录。对纯合小鼠激活的这些细胞的提取物进行 Western blot 分析,证实了此等位基因不编码任何蛋白质。(来源:J:39248)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
366

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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