这种突变在tw73中被发现是一种"寄生性致死"突变,通过重组从单倍体中恢复。完整的murine内源性逆转录病毒(MuERV)插入了第7号内含子。这导致产生了一种异常mRNA,包含1-7号外显子的序列,但缺少8-11号外显子的序列,病毒序列替换了缺失的部分,长度为400bp。(来源:J:115044, J:130178)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
M. m. musculus (Northern Jutland, Denmark)
Spontaneous
病毒插入
隐性
1
1
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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