Grem1^ld-J

A G-to-A transition mutation at the boundary between intron 1 and exon 2 disrupts pre-mRNA splicing by eliminating the AG motif at the 3' splice acceptor site. The aberrant transcript expressed by this allele has a 65 base deletion of the 5' part of exon 2 and is missing the translational start codon. (J:43337, J:91385)