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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
DMTF1 - Cyclin D Binding Myb Like Transcription Factor 1
Alias:
DMP1
DMTF
MRUL
hDMP1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个转录因子,包含一个细胞周期蛋白D结合结构域,三个中央Myb样重复序列,以及N和C端两侧的酸性转激活结构域。该编码蛋白由癌基因Ras信号通路诱导,并通过激活ARF的转录从而激活ARF-p53通路,以阻止细胞生长或诱导凋亡,从而发挥肿瘤抑制因子作用。它还可以激活氨基肽酶N的转录,可能参与造血细胞分化。该蛋白的转录活性受D-细胞周期蛋白的结合调控。这个基因在约40%的人类非小细胞肺癌中半合删除,是非小细胞肺癌的潜在预后和基因治疗靶点。已发现该基因有多种编码不同异型的转录变异体。[RefSeq,2008年12月提供]
Related ID:
NCBI:9988
ENSEMBL:ENSG00000135164
HGNC:14603
UNIPROT:Q9Y222
OMIM:608491
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
9988
51
18
43873 bp
84.47
22
--
2
6
DMTF1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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