人类

DMTF1 - Cyclin D Binding Myb Like Transcription Factor 1

Alias:
DMP1
DMTF
MRUL
hDMP1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个转录因子,包含一个细胞周期蛋白D结合结构域,三个中央Myb样重复序列,以及N和C端两侧的酸性转激活结构域。该编码蛋白由癌基因Ras信号通路诱导,并通过激活ARF的转录从而激活ARF-p53通路,以阻止细胞生长或诱导凋亡,从而发挥肿瘤抑制因子作用。它还可以激活氨基肽酶N的转录,可能参与造血细胞分化。该蛋白的转录活性受D-细胞周期蛋白的结合调控。这个基因在约40%的人类非小细胞肺癌中半合删除,是非小细胞肺癌的潜在预后和基因治疗靶点。已发现该基因有多种编码不同异型的转录变异体。[RefSeq,2008年12月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
51
18
43873 bp
84.47
22
--
2
6

DMTF1 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Comparison
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