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中文人类
MED12 - Mediator Complex Subunit 12
Alias:
Kto
OKS
FGS1
HDKR
HOPA
OPA1
OHDOX
ARC240
CAGH45
MED12S
TNRC11
TRAP230
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预起始复合体是一种大型蛋白质组装，部分控制着转录的起始。这个预起始复合体的一个成分是一个1.2 MDa的蛋白质聚集体，称为Mediator。这个Mediator成分与一个包含这个基因编码的蛋白质（Mediator复合物亚基12，MED12）的CDK8亚复合体结合，还有MED13、CDK8激酶和细胞周期蛋白C。CDK8亚复合体调节Mediator与聚合酶II的相互作用，从而调控转录起始和再起始的速度。MED12蛋白是激活CDK8激酶所必需的。这个基因的缺陷导致X连锁的Opitz-Kaveggia综合征，也称为FG综合征和Lujan-Fryns综合征。[RefSeq，2009年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MED12 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
