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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
TNFSF15 - TNF Superfamily Member 15
Alias:
TL1
TL1A
VEGI
TNLG1B
VEGI192A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种属于肿瘤坏死因子(TNF)配体家族的细胞因子。这种蛋白质在内皮细胞中丰富表达,但在B细胞或T细胞中不表达。这种蛋白质的表达可被TNF和IL-1α诱导。这种细胞因子是受体TNFRSF25的配体,也是诱饵受体TNFRSF21/DR6的配体。它可以激活NF-κB和MAP激酶,并作为内源性因子在内皮细胞中诱导凋亡。这种细胞因子还发现可以抑制内皮细胞增殖,因此可能具有血管生成抑制剂的功能。已经发现这个基因有两个编码不同异型的转录变异体。[RefSeq,2011年2月提供]
Related ID:
NCBI:9966
ENSEMBL:ENSG00000181634
HGNC:11931
UNIPROT:O95150
OMIM:604052
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
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Reference
9966
2
4
21405 bp
28.09
15
1
9
11
TNFSF15 Genetics information (-)
GRCh38
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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