人类

TNFSF15 - TNF Superfamily Member 15

Alias:
TL1
TL1A
VEGI
TNLG1B
VEGI192A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种属于肿瘤坏死因子(TNF)配体家族的细胞因子。这种蛋白质在内皮细胞中丰富表达,但在B细胞或T细胞中不表达。这种蛋白质的表达可被TNF和IL-1α诱导。这种细胞因子是受体TNFRSF25的配体,也是诱饵受体TNFRSF21/DR6的配体。它可以激活NF-κB和MAP激酶,并作为内源性因子在内皮细胞中诱导凋亡。这种细胞因子还发现可以抑制内皮细胞增殖,因此可能具有血管生成抑制剂的功能。已经发现这个基因有两个编码不同异型的转录变异体。[RefSeq,2011年2月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
4
21405 bp
28.09
15
1
9
11

TNFSF15 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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